《搖滾樂團2》(Rock Band 2)繼承了前作的成功之處，內容將更為充實，玩家依然要扮演虛擬樂隊中的成員進行演奏，可演奏的歌曲也將比前作更多。
游戲還改進了網絡對戰模式，前作下載的音樂仍然可以在本作使用，玩家還可以通過網絡下載最新的歌曲進行演奏。
以下是本作著曲目(可能有變動)
Artist Song Title Decade
1. AC/DC “Let There Be Rock” 1970s
2. AFI “Girl’s Gone Grey” 2000’s
3. Alanis Morissette “You Oughta Know” 1990’s
4. Alice in Chains “Man in the Box” 1990’s
5. Allman Brothers “Ramblin’ Man” 1970’s
6. Avenged Sevenfold “Almost Easy” 2000’s
7. Bad Company “Shooting Star” 1970’s
8. Beastie Boys “So Whatcha Want” 1990’s
9. Beck “E-Pro” 2000’s
10. Bikini Kill “Rebel Girl” 1990’s
11. Billy Idol “White Wedding Pt. I” 1980’s
12. Blondie “One Way or Another” 1970’s
13. Bob Dylan “Tangled Up in Blue” 1970’s
14. Bon Jovi “Livin’ on a Prayer” 1980’s
15. Cheap Trick “Hello There” 1970’s
16. Devo “Uncontrollable Urge” 1980’s
17. Dinosaur Jr. “Feel the Pain” 1990’s
18. Disturbed “Down with the Sickness” 2000’s
19. Dream Theater “Panic Attack” 2000’s
20. Duran Duran “Hungry Like the Wolf” 1980’s
21. Elvis Costello “Pump It Up” 1970’s
22. Fleetwood Mac “Go Your Own Way” 1970’s
23. Foo Fighters “Everlong” 1990’s
24. Guns N’ Roses “Shackler’s Revenge” 2000’s
25. Interpol “PDA” 2000’s
26. Jane’s Addiction “Mountain Song” 1980’s
27. Jethro Tull “Aqualung” 1970’s
28. Jimmy Eat World “The Middle” 2000’s
29. Joan Jett “Bad Reputation” 1980’s
30. Journey “Anyway You Want It” 1970’s
31. Judas Priest “Painkiller” 1990’s
32. Kansas “Carry On Wayward Son” 1970’s
33. L7 “Pretend We’re Dead” 1990’s
34. Lacuna Coil “Our Truth” 2000’s
35. Linkin Park “One Step Closer” 2000’s
36. Lit “My Own Worst Enemy” 1990’s
37. Lush “De-Luxe” 1990’s
38. Mastodon “Colony of Birchmen” 2000’s
